Brief Report: The Effect of Antiretroviral Therapy and CD4 Count on Markers of Infectiousness in HIV-Associated Tuberculosis. (1st September 2015)

• Record Type: Journal Article
• Authors: van Halsema, Clare L.; Fielding, Katherine L.; Chihota, Violet N.; George, Elizabeth C.; Lewis, James J.; Churchyard, Gavin J.; Grant, Alison D.
• Is Part Of: Journal of acquired immune deficiency syndromes. Volume 70:Number 1(2015)
• Publication Date: 2015-09-01
• Subjects: HIV-associated tuberculosis -- antiretroviral therapy -- CD4 count -- infectiousness -- pulmonary cavitation; AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome -- Periodicals; AIDS (Disease); Periodicals; 616.9792005
• DOI: 10.1097/QAI.0000000000000684
• Languages: English
• ISSNs: 1525-4135

Abstract

Abstract : Abstract: Clinical features of tuberculosis influence infectiousness. This cross-sectional study examined the effect of combination antiretroviral therapy (cART) and CD4 on sputum smear-positivity (SS+) and pulmonary cavitation among 1589 (1185/1589 HIV-positive) miners in South Africa. Proportions SS+ varied nonlinearly by CD4 with greatest proportions SS+ (55.3%) in the lowest stratum (<100 cells/μL). Adjusted prevalence ratio for SS+; on vs. off cART was 0.90 (95% confidence interval: 0.73 to 1.11). Proportions with cavitation varied linearly with CD4, with no independent cART effect (adjusted prevalence ratio 1.17; 95% confidence interval: 0.80 to 1.71). cART did not independently affect SS+ or cavitation but may increase infectiousness through CD4 recovery. Abstract : Supplemental Digital Content is Available in the Text.