FTO Polymorphism rs9939609 Contributes to Weight Changes in Children With Celiac Disease on Gluten-Free Diet. Issue 2 (August 2015)

• Record Type: Journal Article
• Authors: Grandone, Anna; Marzuillo, Pierluigi; Cirillo, Grazia; Squitieri, Rosanna; Tolone, Salvatore; Miraglia del Giudice, Emanuele; Perrone, Laura; Tolone, Carlo
• Is Part Of: Journal of pediatric gastroenterology and nutrition. Volume 61:Issue 2(2015)
• Publication Date: 2015-08
• Subjects: celiac disease -- obesity -- FTO gene; Children -- Nutrition -- Periodicals; Pediatric gastroenterology -- Periodicals; Infants -- Nutrition -- Periodicals; Nutrition disorders in children -- Periodicals; Child Nutrition -- Periodicals; Digestive System -- growth & development -- Periodicals; Gastrointestinal Diseases -- Periodicals; Infant Nutrition -- Periodicals; Nutrition Disorders -- Periodicals; Child; 618.923
• DOI: 10.1097/MPG.0000000000000724
• Languages: English
• ISSNs: 0277-2116

Abstract

ABSTRACT: Objectives: Studies of adults and children with celiac disease have reported an increased risk of overweight during gluten-free diet (GFD). The fat mass and obesity-associated gene (FTO) variant rs9939609 has been associated with increased risk of developing obesity in children and adults. Methods: In our study, we analyzed the effect of this variant on weight gain in a cohort of 280 children with celiac disease on GFD. Results: We found that after a mean follow-up time of 3.0 years on GFD, FTO polymorphism influenced significantly the mean change in body mass index z score ( P = 0.01). Conclusions: We conclude that the FTO gene contributes to determine weight changes in children with celiac disease on GFD.