Genomic Meningococcal Load in the Nasopharynx of Children with Meningococcal Disease. Issue 5 (May 2016)

• Record Type: Journal Article
• Authors: Bourke, Thomas W.; McKenna, James P.; Coyle, Peter V.; Fairley, Derek J.; Shields, Michael D.
• Is Part Of: Pediatric infectious disease journal. Volume 35:Issue 5(2016)
• Publication Date: 2016-05
• Subjects: meningococcal disease -- Neisseria meningitidis -- bacterial load; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000001079
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : This study demonstrates the feasibility of using quantitative real time PCR to measure genomic bacterial load in the nasopharynx of children with invasive meningococcal disease and shows that these loads are exceptionally high (median 6.6 × 10 5 (range 1.2 × 10 5 –1.1 × 10 8 ) genome copies of Neisseria meningitidis per swab). Abstract : Supplemental Digital Content is available in the text.