Impact of the Increased Recommended Dosage of Isoniazid on Pyridoxine Levels in Children and Adolescents. Issue 5 (May 2016)

• Record Type: Journal Article
• Authors: Rodà, Diana; Rozas, Librada; Fortuny, Clàudia; Sierra, Cristina; Noguera-Julian, Antoni
• Is Part Of: Pediatric infectious disease journal. Volume 35:Issue 5(2016)
• Publication Date: 2016-05
• Subjects: isoniazid -- peripheral neuropathy -- pyridoxine -- tuberculosis -- vitamin B6; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000001084
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : Isoniazid exposure causes dose-dependent pyridoxine deficiency. Recently, the recommended dosage of isoniazid in children was increased from 5 (4–6) to 10 (10–15) mg/kg/day. We aimed to analyze longitudinally pyridoxine levels in a cohort of previously healthy children and adolescents treated with isoniazid. Mild symptom-free pyridoxine deficiency was observed in 4/75 (5.6%) and 3/40 (7.5%) at baseline and at 3-month follow-up, respectively. Classical age-related risk factors identified patients at risk of pyridoxine deficiency. Our preliminary results support current recommendations regarding pyridoxine supplementation in healthy children. Abstract : Supplemental Digital Content is available in the text.