Early autologous fresh whole blood transfusion leads to less allogeneic transfusions and is safe. Issue 4 (April 2015)

• Record Type: Journal Article
• Authors: Rhee, Peter; Inaba, Kenji; Pandit, Viraj; Khalil, Mazhar; Siboni, Stefano; Vercruysse, Gary; Kulvatunyou, Narong; Tang, Andrew; Asif, Anum; O'Keeffe, Terence; Joseph, Bellal
• Is Part Of: Journal of trauma and acute care surgery. Volume 78:Issue 4(2015:Apr.)
• Publication Date: 2015-04
• Subjects: Autologous transfusion -- whole blood autotransfusion -- trauma; Surgical intensive care -- Periodicals; Surgical emergencies -- Periodicals; Wounds and injuries -- Surgery -- Periodicals; 617.026
• DOI: 10.1097/TA.0000000000000599
• Languages: English
• ISSNs: 2163-0755

Abstract

Abstract : BACKGROUND: The practice of transfusing ones' own shed whole blood has obvious benefits such as reducing the need for allogeneic transfusions and decreasing the need for other fluids that are typically used for resuscitation in trauma. It is not widely adopted in the trauma setting because of the concern of worsening coagulopathy and the inflammatory process. The aim of this study was to assess outcomes in trauma patients receiving whole blood autotransfusion (AT) from hemothorax. METHODS: This is a multi-institutional retrospective study of all trauma patients who received autologous whole blood transfusion from hemothorax from two Level I trauma centers. Patients who received AT were matched to patients who did not receive AT (No-AT) using propensity score matching in a 1:1 ratio for admission age, sex, mechanism, type of injury, Injury Severity Score (ISS), Glasgow Coma Scale (GCS) score, systolic blood pressure, heart rate, hemoglobin, international normalized ratio (INR), prothrombin time, partial prothrombin time, and lactate. AT was defined as transfusion of autologous blood from patient's hemothorax, which was collected from the chest tubes and anticoagulated with citrate phosphorous dextrose. Outcome measures were in-hospital complications, 24-hour INR, and mortality. In-hospital complications were defined as adult respiratory distress syndrome, sepsis, disseminated intravascular coagulation, renal insufficiency, and transfusion-related acute lung injury. RESULTS: A total of 272 patients (AT, 136; No-AT, 136) were included. There was no difference in admission age ( p = 0.6), ISS ( p = 0.56), head Abbreviated Injury Scale (AIS) score ( p = 0.42), systolic blood pressure ( p = 0.88), and INR ( p = 0.62) between the two groups. There was no significant difference in in-hospital complications ( p = 0.61), mortality ( p = 0.51), and 24-hour postadmission INR (0.31) between the AT and No-AT groups. Patients who received AT had significantly lower packed red blood cell ( p = 0.01) and platelet requirements ( p = 0.01). Cost of transfusions ( p = 0.01) was significantly lower in the AT group compared with the No-AT group. CONCLUSION: The autologous transfusion of the patient's shed blood collected through chest tubes for hemothorax was found to be safe without complications in this study. It also reduced the need for allogeneic transfusions and decreased hospital costs. This study demonstrates safety data that would help in designing larger prospective multicenter studies to determine whether this practice is truly safe and effective. LEVEL OF EVIDENCE: Epidemiologic/prognostic study, level III.