Role of Oral Anticoagulants in Patients After an Acute Coronary Syndrome. Issue 3 (March 2015)

• Record Type: Journal Article
• Authors: Carreras, Edward T.; Mega, Jessica L.
• Is Part Of: Arteriosclerosis, thrombosis, and vascular biology. Volume 35:Issue 3(2015)
• Publication Date: 2015-03
• Subjects: acute coronary syndrome -- anticoagulation -- non-vitamin K dependent oral anticoagulants; Arteriosclerosis -- Periodicals; Thrombosis -- Periodicals; Blood-vessels -- Pathophysiology -- Periodicals; Electronic journals; 616.13
• DOI: 10.1161/ATVBAHA.114.303401
• Languages: English
• ISSNs: 1079-5642

Abstract

Abstract : After an acute coronary syndrome, patients continue to be at risk of adverse cardiovascular events despite treatment with the current standard of antithrombotic therapy. The risk may be in part secondary to thrombin, which remains elevated after an acute coronary syndrome event. Several studies have investigated the utility of adding oral anticoagulation to post-acute coronary syndrome medical regimens, with the most promising results coming from the addition of low-dose oral direct anticoagulants. Focusing on optimal dosing strategies and applying therapies to the appropriate populations provide the ability to maximize benefit and minimize risk.