Consistency of metabolic tumor volume of non-small-cell lung cancer primary tumor measured using 18F-FDG PET/CT at two different tracer uptake times. Issue 1 (January 2016)

• Record Type: Journal Article
• Authors: Liu, Haiping; Chen, Ping; Wroblewski, Kristen; Hou, Peng; Zhang, Chen-Peng; Jiang, Yulei; Pu, Yonglin
• Is Part Of: Nuclear medicine communications. Volume 37:Issue 1(2016:Jan.)
• Publication Date: 2016-01
• Subjects: 18F-fluorodeoxyglucose -- metabolic tumor burden -- metabolic tumor volume -- non-small-cell lung cancer -- total lesion glycolysis; Nuclear medicine -- Periodicals; 616.07575
• DOI: 10.1097/MNM.0000000000000396
• Languages: English
• ISSNs: 0143-3636

Abstract

Abstract : Objectives: The objective of this study was to test the hypothesis that the metabolic tumor volume (MTV) of primary non-small-cell lung cancer is not sensitive to differences in 18 F-fluorodeoxyglucose ( 18 F-FDG) uptake time, and to compare this consistency of MTV measurements with that of standardized uptake value (SUV) and total lesion glycolysis (TLG). Methods: Under Institutional Review Board approval, 134 consecutive patients with histologically proven non-small-cell lung cancer underwent 18 F-FDG PET/computed tomography scanning at about 1 h (early) and 2 h (delayed) after intravenous injection of 18 F-FDG. MTV, SUV, and TLG of the primary tumor were all measured. Student's t -test and Wilcoxon's signed-rank test for paired data were used to compare MTV, SUV, and TLG between the two scans. The intraclass correlation coefficient (ICC) was used to assess agreement in PET parameters between the two scans and between the measurements made by two observers. Results: MTV was not significantly different ( P =0.17) between the two scans. However, SUVmax, SUVmean, SUVpeak, and TLG increased significantly from the early to the delayed scans ( P <0.0001 for all). The median percentage change between the two scans in MTV (1.65%) was smaller than in SUVmax (11.76%), SUVmean (10.57%), SUVpeak (13.51%), and TLG (14.34%); the ICC of MTV (0.996) was greater than that of SUVmax (0.933), SUVmean (0.952), SUVpeak (0.928), and TLG (0.982). Interobserver agreement between the two radiologists was excellent for MTV, SUV, and TLG on both scans (ICC: 0.934–0.999). Conclusion: MTV is not sensitive to common clinical variations in 18 F-FDG uptake time, its consistency is greater than that of SUVmax, SUVmean, SUVpeak, and TLG, and it has excellent interobserver agreement.