Pancreatic Retransplantation Is Associated With Poor Allograft Survival: An Update of the United Network for Organ Sharing Database. Issue 5 (July 2015)

• Record Type: Journal Article
• Authors: Siskind, Eric; Maloney, Caroline; Jayaschandaran, Vivek; Kressel, Adam; Akerman, Meredith; Shen, Adam; Amodu, Leo; Platz, John; Ricci, John P.; Bhaskaran, Madhu; Basu, Amit; Molmenti, Ernesto; Ortiz, Jorge
• Is Part Of: Pancreas. Volume 44:Issue 5(2015)
• Publication Date: 2015-07
• Subjects: pancreas transplantation -- allograft failure -- retransplantation -- survival analysis -- rejection -- thrombosis; Pancreas -- Diseases -- Periodicals; Pancreas -- Periodicals; Neuroendocrine tumors -- Periodicals; 616.37005
• DOI: 10.1097/MPA.0000000000000330
• Languages: English
• ISSNs: 0885-3177

Abstract

Objective: The aim of the study was to assess outcomes of pancreas retransplantation versus primary pancreas transplantation. Methods: Data from the United Network for Organ Sharing database on all adult (age, ≥18 years) subjects who received pancreas and kidney-pancreas transplants between 1996 and 2012 were analyzed (n = 20, 854). The subjects were analyzed in the following 2 groups: retransplant (n = 1149) and primary transplant (n = 19, 705). Results: Kaplan-Meier analysis demonstrated significantly different patient survival ( P < 0.0001) and death-censored graft survival ( P < 0.0001) between the primary transplant versus retransplant subjects. Allograft survival was significantly poorer in the retransplantation group. Patient survival was greater in the retransplant group. Conclusions: The results of our study differ from previous studies, which showed similar allograft survival in primary and secondary pancreas transplants. Further studies may elucidate specific patients who will benefit from retransplantation. At the present time, it would appear that pancreas retransplantation is associated with poor graft survival and that retransplantation should not be considered for all patients with primary pancreatic allograft failure.