Distribution of TRPV1 and TRPV2 in the human stellate ganglion and spinal cord. (17th March 2015)

• Record Type: Journal Article
• Authors: Kokubun, Souichi; Sato, Tadasu; Ogawa, Chikara; Kudo, Kai; Goto, Koju; Fujii, Yuki; Shimizu, Yoshinaka; Ichikawa, Hiroyuki
• Is Part Of: Neuroscience letters. Volume 590(2015)
• Page Start: 6
• Page End: 11
• Publication Date: 2015-03-17
• Subjects: Stellate ganglion -- TRPV1 -- TRPV2 -- Spinal cord -- Human -- Immunohistochemistry; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2015.01.074
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: TRPV1 and TRPV2 channels are multimodal sensors. Sympathetic neurons in human stellate ganglion contained TRPV1 and TRPV2. Sympathetic neurons were surrounded by TRPV2-containing nerve fibers. Lateral horn neurons in human spinal cord have TRPV2. There is TRPV1- or TRPV2-containing sympathetic pathway in stellate ganglion and spinal cord. Abstract: Immunohistochemistry for the transient receptor potential cation channel subfamily V member 1 (TRPV1) and 2 (TRPV2) was performed on the stellate ganglion and spinal cord in human cadavers. In the stellate ganglion, 25.3% and 16.2% of sympathetic neurons contained TRPV1- and TRPV2-immunoreactivity, respectively. The cell size analysis also demonstrated that proportion of TRPV1- or TRPV2-immunoreactive (-IR) neurons among large (>600 μm 2 ) sympathetic neurons (TRPV1, 30.7%; TRPV2, 27.0%) was higher than among small (<600 μm 2 ) sympathetic neurons (TRPV1, 22.0%; TRPV2, 13.6%). The present study also demonstrated that 10.0% of sympathetic neurons in the stellate ganglion had pericellular TRPV2-IR nerve fibers. Fourteen percent of large neurons and 7.8% of small neurons were surrounded by TRPV2-IR nerve fibers. TRPV2-immunoreactivity was also detected in about 40% of neuronal cell bodies with pericellular TRPV2-IR nerve fibers. In the lateral horn of the human thoracic spinal cord, TRPV2-immunoreactivity was expressed by some neurons and many varicose fibers surrounding TRPV2-immunonegative neurons. TRPV2-IR pericellular fibers in the stellate ganglion may originate from the lateral horn of the spinal cord. There appears to be TRPV1- or TRPV2-IR sympathetic pathway in the human stellate ganglion and spinal cord.