Enantioselective Direct Synthesis of syn‐ and anti‐α, β‐Dihydroxy γ‐Keto Esters Using a Dinuclear Zinc–AzePhenol Complex. Issue 6 (12th February 2018)

• Record Type: Journal Article
• Authors: Zhang, Zhao‐Fei; Yang, Xiao‐Chao; Lu, Hui‐Jie; Wang, Min‐Can
• Is Part Of: European journal of organic chemistry. Issue 6(2018)
• Page Start: 785
• Page End: 793
• Publication Date: 2018-02-12
• Subjects: Aldol reactions -- Zinc -- Ligand design -- Dinuclear complexes -- N, O ligands -- Keto esters; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201701695
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : A one‐step enantioselective direct synthesis of both syn ‐ and anti ‐α, β‐dihydroxy γ‐keto esters using a dinuclear zinc–AzePhenol complex is presented. This asymmetric α‐hydroxyacetate aldol reaction proceeds in moderate to good yield and with excellent enantioselectivity of up to 99 % ee . The desired products could be used as versatile intermediates for several transformations. Abstract : A one‐step enantioselective direct synthesis of both syn ‐ and anti ‐α, β‐dihydroxy γ‐keto esters using a dinuclear zinc–AzePhenol complex is presented. This asymmetric α‐hydroxyacetate aldol reaction proceeds in moderate to good yield and with excellent enantioselectivity of up to 99 % ee . The desired products could be used as versatile intermediates for several transformations.