Homeobox transcription factor DLX4 is not necessary for skin development and homeostasis. Issue 3 (8th March 2018)

• Record Type: Journal Article
• Authors: Bhattacharya, Shreya; Duverger, Olivier; Brooks, Stephen R.; Morasso, Maria I.
• Is Part Of: Experimental dermatology. Volume 27:Issue 3(2018)
• Page Start: 289
• Page End: 292
• Publication Date: 2018-03-08
• Subjects: Dlx4 -- epidermis -- homeobox transcription factor -- skin homeostasis; Dermatology -- Periodicals; 616.5
• DOI: 10.1111/exd.13503
• Languages: English
• ISSNs: 0906-6705

Abstract

Abstract: Dlx4 is a member of a family of homeobox genes with homology to Drosophila distal‐less ( dll ) gene. We show that Dlx4 expression pattern partially overlaps with its cis‐linked gene Dlx3 during mouse development as well as in neonatal and adult skin. In mice, Dlx4 is expressed in the branchial arches, embryonic limbs, digits, nose, hair follicle and in the basal and suprabasal layers of mouse interfollicular epidermis. We show that inactivation of Dlx4 in mice did not result in any overtly gross pathology. Skin development, homeostasis and response to TPA treatment were similar in mice with loss of Dlx4 compared to wild‐type counterparts.