1H‐1, 2, 3‐Triazole‐tethered Isatin–coumarin Hybrids: Design, Synthesis and In Vitro Anti‐mycobacterial Evaluation. (12th January 2018)
- Record Type:
- Journal Article
- Title:
- 1H‐1, 2, 3‐Triazole‐tethered Isatin–coumarin Hybrids: Design, Synthesis and In Vitro Anti‐mycobacterial Evaluation. (12th January 2018)
- Main Title:
- 1H‐1, 2, 3‐Triazole‐tethered Isatin–coumarin Hybrids: Design, Synthesis and In Vitro Anti‐mycobacterial Evaluation
- Authors:
- Liu, Bi
Hu, Guowen
Tang, Xiuqin
Wang, Guangqiang
Xu, Zhi - Abstract:
- Abstract : A series of novel 1 H ‐1, 2, 3‐triazole‐tethered isatin–coumarin hybrids7a –l integrate three anti‐tuberculosis bioactive substances/pharmacophoric units including coumarin, isatin, andI ‐A09 were designed, synthesized, and tested for their in vitro anti‐mycobacterial activity against Mycobacterium smegmatis and Mycobacterium tuberculosis H37Rv as well as cytotoxicity in VERO cell line. The results showed that all hybrids exhibited weak to moderate activity against the tested two strains with minimum inhibitory concentration ranging from 50 to 200 μg/mL. Abstract :
- Is Part Of:
- Journal of heterocyclic chemistry. Volume 55:Number 3(2018)
- Journal:
- Journal of heterocyclic chemistry
- Issue:
- Volume 55:Number 3(2018)
- Issue Display:
- Volume 55, Issue 3 (2018)
- Year:
- 2018
- Volume:
- 55
- Issue:
- 3
- Issue Sort Value:
- 2018-0055-0003-0000
- Page Start:
- 775
- Page End:
- 780
- Publication Date:
- 2018-01-12
- Subjects:
- Heterocyclic compounds -- Periodicals
547.59 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.1002/jhet.3093 ↗
- Languages:
- English
- ISSNs:
- 0022-152X
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 4998.200000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 5970.xml