An Integrated Multifunctional Nanoplatform for Deep‐Tissue Dual‐Mode Imaging. (22nd January 2018)
- Record Type:
- Journal Article
- Title:
- An Integrated Multifunctional Nanoplatform for Deep‐Tissue Dual‐Mode Imaging. (22nd January 2018)
- Main Title:
- An Integrated Multifunctional Nanoplatform for Deep‐Tissue Dual‐Mode Imaging
- Authors:
- Yang, Fan
Skripka, Artiom
Benayas, Antonio
Dong, Xianke
Hong, Sung Hwa
Ren, Fuqiang
Oh, Jung Kwon
Liu, Xinyu
Vetrone, Fiorenzo
Ma, Dongling - Abstract:
- Abstract: The combination of biocompatible superparamagnetic and photoluminescent nanoparticles (NPs) is intensively studied as highly promising multifunctional (magnetic confinement and targeting, imaging, etc.) tools in biomedical applications. However, most of these hybrid NPs exhibit low signal contrast and shallow tissue penetration for optical imaging due to tissue‐induced optical extinction and autofluorescence, since in many cases, their photoluminescent components emit in the visible spectral range. Yet, the search for multifunctional NPs suitable for high photoluminescence signal‐to‐noise ratio, deep‐tissue imaging is still ongoing. Herein, a biocompatible core/shell/shell sandwich structured Fe3 O4 @SiO2 @NaYF4 :Nd 3+ nanoplatform possessing excellent superparamagnetic and near‐infrared (excitation) to near‐infrared (emission), i.e., NIR‐to‐NIR photoluminescence properties is developed. They can be rapidly magnetically confined, allowing the NIR photoluminescence signal to be detected through a tissue as thick as 13 mm, accompanied by high T2 relaxivity in magnetic resonance imaging. The fact that both the excitation and emission wavelengths of these NPs are in the optically transparent biological windows, along with excellent photostability, fast magnetic response, significant T2 ‐contrast enhancement, and negligible cytotoxicity, makes them extremely promising for use in high‐resolution, deep‐tissue dual‐mode (optical and magnetic resonance) in vivo imaging andAbstract: The combination of biocompatible superparamagnetic and photoluminescent nanoparticles (NPs) is intensively studied as highly promising multifunctional (magnetic confinement and targeting, imaging, etc.) tools in biomedical applications. However, most of these hybrid NPs exhibit low signal contrast and shallow tissue penetration for optical imaging due to tissue‐induced optical extinction and autofluorescence, since in many cases, their photoluminescent components emit in the visible spectral range. Yet, the search for multifunctional NPs suitable for high photoluminescence signal‐to‐noise ratio, deep‐tissue imaging is still ongoing. Herein, a biocompatible core/shell/shell sandwich structured Fe3 O4 @SiO2 @NaYF4 :Nd 3+ nanoplatform possessing excellent superparamagnetic and near‐infrared (excitation) to near‐infrared (emission), i.e., NIR‐to‐NIR photoluminescence properties is developed. They can be rapidly magnetically confined, allowing the NIR photoluminescence signal to be detected through a tissue as thick as 13 mm, accompanied by high T2 relaxivity in magnetic resonance imaging. The fact that both the excitation and emission wavelengths of these NPs are in the optically transparent biological windows, along with excellent photostability, fast magnetic response, significant T2 ‐contrast enhancement, and negligible cytotoxicity, makes them extremely promising for use in high‐resolution, deep‐tissue dual‐mode (optical and magnetic resonance) in vivo imaging and magnetic‐driven applications. Abstract : Core/shell/shell Fe3 O4 @SiO2 @NaYF4 :Nd 3+ nanoplatforms possess excellent superparamagnetic and near‐infrared (excitation) to near‐infrared (emission) photoluminescence properties, which allow the NIR photoluminescence signal to be detected through a tissue as thick as 13 mm. These features make them extremely promising for use in high‐resolution, deep‐tissue dual‐mode (optical and magnetic resonance) imaging in vivo. … (more)
- Is Part Of:
- Advanced functional materials. Volume 28:Number 11(2018)
- Journal:
- Advanced functional materials
- Issue:
- Volume 28:Number 11(2018)
- Issue Display:
- Volume 28, Issue 11 (2018)
- Year:
- 2018
- Volume:
- 28
- Issue:
- 11
- Issue Sort Value:
- 2018-0028-0011-0000
- Page Start:
- n/a
- Page End:
- n/a
- Publication Date:
- 2018-01-22
- Subjects:
- deep‐tissue optical imaging -- dual‐mode imaging -- magnetic resonance imaging -- multifunctional nanoparticles -- near‐infrared to near‐infrared
Materials -- Periodicals
Chemical vapor deposition -- Periodicals
620.11 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1616-3028 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1002/adfm.201706235 ↗
- Languages:
- English
- ISSNs:
- 1616-301X
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 0696.853900
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 5972.xml