Associative fear learning and perceptual discrimination: A perceptual pathway in the development of chronic pain. (April 2015)

• Record Type: Journal Article
• Authors: Zaman, Jonas; Vlaeyen, Johan W.S.; Van Oudenhove, Lukas; Wiech, Katja; Van Diest, Ilse
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 51(2015:Apr.)
• Page Start: 118
• Page End: 125
• Publication Date: 2015-04
• Subjects: Associative fear learning -- Perceptual discrimination -- Pain perception -- Chronic pain; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2015.01.009
• Languages: English
• ISSNs: 0149-7634

Abstract

Highlights: Chronic pain patients display impaired discrimination of bodily sensations. The experience of pain triggers fear learning processes. Fear learning influences perceptual discrimination. The learning experience moderates learning-induced changes in discrimination. This mechanism is proposed to contribute to the development of chronic pain. Abstract: Recent neuropsychological theories emphasize the influence of maladaptive learning and memory processes on pain perception. However, the precise relationship between these processes as well as the underlying mechanisms remain poorly understood; especially the role of perceptual discrimination and its modulation by associative fear learning has received little attention so far. Experimental work with exteroceptive stimuli consistently points to effects of fear learning on perceptual discrimination acuity. In addition, clinical observations have revealed that in individuals with chronic pain perceptual discrimination is impaired, and that tactile discrimination training reduces pain. Based on these findings, we present a theoretical model of which the central tenet is that associative fear learning contributes to the development of chronic pain through impaired interoceptive and proprioceptive discrimination acuity.