Urinary trypsin inhibitor levels are reduced in cerebrospinal fluid of multiple sclerosis and neuromyelitis optica patients during relapse. (February 2015)

• Record Type: Journal Article
• Authors: Shu, Yaqing; Li, Rui; Yang, Yu; Dai, Yongqiang; Qiu, Wei; Chen, Ying; Zhao, Zhihua; Lu, Zhengqi; Hu, Xueqiang
• Is Part Of: Neurochemistry international. Volume 81(2015)
• Page Start: 28
• Page End: 31
• Publication Date: 2015-02
• Subjects: MS multiple sclerosis -- NMO neuromyelitis optica -- CNS central nervous system -- EAE experimental autoimmune encephalomyelitis -- UTI urinary trypsin inhibitor -- ITI inter-α-trypsin inhibitor -- CSF cerebrospinal fluid -- EDSS Expanded Disability Status Scale -- ELISA enzyme-linked immunosorbent assay -- OCB oligoclonal bands -- NE neutrophil elastase -- WBC white blood cells -- TP total protein -- Glu glucose -- CL chlorine; Urinary trypsin inhibitor -- Cerebrospinal fluid -- Multiple sclerosis -- Neuromyelitis optica; Neurochemistry -- Periodicals; Neurochemistry -- Periodicals; Neurochimie -- Périodiques; Neurochemistry; Periodicals; 612.804205
• DOI: 10.1016/j.neuint.2014.12.008
• Languages: English
• ISSNs: 0197-0186

Abstract

Highlights: CSF UTI levels were reduced in MS and NMO patients during relapse. CSF UTI levels were negatively associated with MS and NMO severity during relapse. CSF UTI levels were not significantly associated with routine CSF in MS and NMO. Abstract: Background: Neutrophil-mediated inflammation plays an important role in the pathogenesis of multiple sclerosis (MS) and neuromyelitis optica (NMO). Concentrations of urinary trypsin inhibitor (UTI) have attracted attention as a useful index of the status of inflammatory response. Evidence suggests serum UTI levels are increased in some inflammatory diseases, but little attention has been paid to cerebrospinal fluid (CSF) levels of UTI. Objective: To measure CSF concentration of UTI and determine its relationship with disease activity in MS and NMO. Methods: CSF UTI was measured by an enzyme-linked immunosorbent assay in 18 MS patients, 28 NMO patients and eight controls. Results: CSF UTI concentrations in MS and NMO groups were both significantly lower than those in controls. Expanded disability status scale scores of MS and NMO revealed a trend of increased disease disability with decreased CSF UTI level. The CSF UTI concentrations were not significantly associated with CSF white blood cell counts, total protein, glucose and chlorine concentrations in MS and NMO subgroups. Conclusions: Our results indicate a reduced UTI level in CSF of MS and NMO patients. The levels were associated with the severity of the two demyelinating diseases during relapse.