A comparison study of haemolysis production in three contemporary centrifugal pumps. (September 2014)

• Record Type: Journal Article
• Authors: Bottrell, S; Bennett, M; Augustin, S; Thuys, C; Schultz, B; Horton, A; Horton, S
• Is Part Of: Perfusion. Volume 29:Number 5(2014)
• Page Start: 411
• Page End: 416
• Publication Date: 2014-09
• Subjects: centrifugal pump -- haemolysis -- ECMO -- diagonal pump -- VAD -- hybrid pump -- ECLS; Perfusion (Physiology) -- Periodicals; Blood -- Circulation, Artificial -- Periodicals; Heart -- Surgery -- Periodicals; Extracorporeal Circulation -- Periodicals; Perfusion -- Periodicals; Circulation extracorporelle -- Périodiques; Perfusion -- Périodiques; 617.41
• DOI: 10.1177/0267659113509000
• Languages: English
• ISSNs: 0267-6591

Abstract

One challenge in providing extracorporeal circulation is to supply optimal flow while minimising adverse effects, such as haemolysis. To determine if the recent generation constrained vortex pumps with their inherent design improvements would lead to reduced red cell trauma, we undertook a study comparing three devices. Utilizing a simulated short-term ventricular assist circuit primed with whole human blood, we examined changes in plasma free haemoglobin values over a six-day period. The three pumps investigated were the Maquet Rotaflow, the Levitronix PediVAS and the Medos Deltastream DP3.This study demonstrated that all three pumps produced low levels of haemolysis and are suitable for use in a clinical environment. The Levitronix PediVAS was significantly less haemolytic than either the Rotaflow (p<0.05) or the DP3 (p<0.05). There was no significant difference in plasma free haemoglobin between the Rotaflow and the DP3 (p=0.71).