Botanical compounds and their regulation of nuclear receptor action: The case of traditional Chinese medicine. (5th February 2015)

• Record Type: Journal Article
• Authors: Li, Ling; Bonneton, François; Chen, Xiao Yong; Laudet, Vincent
• Is Part Of: Molecular and cellular endocrinology. Volume 401(2015)
• Page Start: 221
• Page End: 237
• Publication Date: 2015-02-05
• Subjects: AR androgen receptor -- CAR constitutive androstane receptor -- DBD DNA-binding domain -- EDC endocrine disrupting chemical -- ER estrogen receptor -- FXR farnesoid X receptor -- GR glucocorticoid receptor -- HRE hormone responsive elements -- LBD ligand-binding domain -- LXR liver X receptor -- NGF-IB nerve growth factor-IB -- NR nuclear receptor -- NURR1 nuclear receptor related 1 -- PPAR peroxisome proliferator activated receptor -- PXR pregnane X receptor -- RAR retinoid acid receptor -- RXR retinoid X receptor -- SERM selective estrogen receptor modulator -- SHP small heterodimer partner -- SNuRMs selective nuclear receptor modulators -- SRC steroid receptor coactivator -- TCM traditional Chinese medicine -- TR thyroid receptor -- VDR vitamin D receptor; Nuclear receptor -- Traditional Chinese medicine -- Pharmacology -- Agonist -- Antagonist; Endocrinology -- Periodicals; Molecular biology -- Periodicals; Cytology -- Periodicals; Endocrinology -- Periodicals; Hormones -- Periodicals; Endocrinologie -- Périodiques; Cytology; Endocrinology; Molecular biology; Periodicals; 573.4
• DOI: 10.1016/j.mce.2014.10.028
• Languages: English
• ISSNs: 0303-7207

Abstract

Highlights: Nuclear receptors are targets of compounds from traditional Chinese herbal remedies. We review the mechanisms of action of botanical compounds on nuclear receptors. We exemplify actions mediated by steroid receptors, metabolic receptors and RXR. We draw a parallel between TCMs and phytoestrogens or endocrine disruptors. We define common principle and highlight potential and limits of active compounds. Abstract: Nuclear receptors (NRs) are major pharmacological targets that allow an access to the mechanisms controlling gene regulation. As such, some NRs were identified as biological targets of active compounds contained in herbal remedies found in traditional medicines. We aim here to review this expanding literature by focusing on the informative articles regarding the mechanisms of action of traditional Chinese medicines (TCMs). We exemplified well-characterized TCM action mediated by NR such as steroid receptors (ER, GR, AR), metabolic receptors (PPAR, LXR, FXR, PXR, CAR) and RXR. We also provided, when possible, examples from other traditional medicines. From these, we draw a parallel between TCMs and phytoestrogens or endocrine disrupting chemicals also acting via NR. We define common principle of action and highlight the potential and limits of those compounds. TCMs, by finely tuning physiological reactions in positive and negative manners, could act, in a subtle but efficient way, on NR sensors and their transcriptional network.