Clinical Value of Visually Identifiable 18F-fluorodeoxyglucose Uptake in Primary Papillary Thyroid Microcarcinoma. (September 2014)

• Record Type: Journal Article
• Authors: Hwang, Seung Ook; Lee, Sang-Woo; Kang, Jin Koo; Choi, Hyang Hee; Kim, Wan Wook; Park, Ho Yong; Jung, Jin Hyang
• Is Part Of: Otolaryngology--head and neck surgery. Volume 151:Number 3(2014:Sep.)
• Page Start: 415
• Page End: 420
• Publication Date: 2014-09
• Subjects: papillary thyroid microcarcinoma -- 18F-fluorodeoxyglucose uptake -- positron emission tomography/computed tomography -- extrathyroidal invasion -- lymph node metastasis; Head -- Surgery -- Periodicals; Neck -- Surgery -- Periodicals; Otolaryngology -- Periodicals; 617.51
• DOI: 10.1177/0194599814537224
• Languages: English
• ISSNs: 0194-5998

Abstract

Objective: This study evaluates the relationship between visually identifiable 18 F-fluorodeoxyglucose (FDG) uptake in primary papillary thyroid microcarcinoma (PTMC) and tumor aggressiveness. Study Design: Historical cohort study. Setting: Tertiary care center. Methods: Clinicopathological factors and PET/CT findings of 219 PTMC surgical patients who underwent preoperative 18 F-FDG positron emission tomography/computed tomography (PET/CT) were retrospectively reviewed. Results: 18 F-FDG uptake was observed in the tumors of 124 (56.6%) patients. Tumor size (odds ratio [OR] = 1.774; 95% confidence interval [CI], 1.416-2.223; P < .0001) and Hashimoto thyroiditis (OR = 2.815; CI, 1.237-6.404; P = .014) independently predicted 18 F-FDG uptake. Tumor size (OR = 1.495; CI, 1.217-1.835; P < .0001) and BRAF V600E mutation (OR = 3.320; CI, 1.056-10.432; P = .040) independently predicted extrathyroidal invasion. Multiplicity (OR = 2.375; CI, 1.278-4.415; P = .006) independently predicted central lymph node metastasis. Conclusion: 18 F-FDG uptake in PTMC depends on tumor size and Hashimoto thyroiditis. Therefore, preoperative PET/CT for PTMC may not help in evaluating tumor aggressiveness.