Flexible End2End Workflow Automation of Hit-Discovery Research. (August 2014)

• Record Type: Journal Article
• Authors: Holzmüller-Laue, Silke; Göde, Bernd; Thurow, Kerstin
• Is Part Of: Journal of laboratory automation. Volume 19:Number 4(2014:Aug.)
• Page Start: 349
• Page End: 361
• Publication Date: 2014-08
• Subjects: laboratory automation -- end2end workflow -- systems integration -- human task support -- Business Process Model and Notation (BPMN); Medical laboratory technology -- Periodicals; Laboratories -- Equipment and supplies -- Periodicals; Diagnosis, Laboratory -- Periodicals; 616.075
• DOI: 10.1177/2211068213520402
• Languages: English
• ISSNs: 2211-0682

Abstract

The article considers a new approach of more complex laboratory automation at the workflow layer. The authors purpose the automation of end2end workflows. The combination of all relevant subprocesses—whether automated or manually performed, independently, and in which organizational unit—results in end2end processes that include all result dependencies. The end2end approach focuses on not only the classical experiments in synthesis or screening, but also on auxiliary processes such as the production and storage of chemicals, cell culturing, and maintenance as well as preparatory activities and analyses of experiments. Furthermore, the connection of control flow and data flow in the same process model leads to reducing of effort of the data transfer between the involved systems, including the necessary data transformations. This end2end laboratory automation can be realized effectively with the modern methods of business process management (BPM). This approach is based on a new standardization of the process-modeling notation Business Process Model and Notation 2.0. In drug discovery, several scientific disciplines act together with manifold modern methods, technologies, and a wide range of automated instruments for the discovery and design of target-based drugs. The article discusses the novel BPM-based automation concept with an implemented example of a high-throughput screening of previously synthesized compound libraries.