Sleep disorders in systemic lupus erythematosus. Does vitamin D play a role?. (September 2014)

• Record Type: Journal Article
• Authors: Gholamrezaei, A; Bonakdar, Z Sayed; Mirbagher, L; Hosseini, N
• Is Part Of: Lupus. Volume 23:Number 10(2014)
• Page Start: 1054
• Page End: 1058
• Publication Date: 2014-09
• Subjects: Systemic lupus erythematosus -- sleep -- sleep disorders -- vitamin D deficiency; Systemic lupus erythematosus -- Periodicals; 616.772005
• DOI: 10.1177/0961203314532563
• Languages: English
• ISSNs: 0961-2033

Abstract

Objectives: Sleep disorders are common among patients with systemic lupus erythematosus (SLE) with unclear underlying mechanisms. We assessed the role of vitamin D in sleep quality of patients with SLE. Methods: A retrospective study was conducted on women with SLE for whom the following data were available at the same time; sleep quality (Pittsburgh Sleep Quality Index (PSQI)), disease activity, cumulative disease damage, psychological state (Hospital Anxiety and Depression Scale (HADS)), and serum vitamin D level. Bivariate and regression analyses were computed to find contributors of sleep quality. Results: In total, 63 women were studied. Serum vitamin D level was correlated with physical activity ( r = 0.310, p = 0.015), season of assessment ( r = −0.302, p = 0.016), the PSQI global score ( r = −0.262, p = 0.043), anxiety score ( r = −0.298, p = 0.021), and non-significantly with depression score ( r = −0.218, p = 0.094). Including all variables into a linear regression model, vitamin D level was independently associated with the global PSQI score (beta = −0.364, p = 0.042). Association of vitamin D level with psychological state disappeared after controlling for season of assessment (beta = −0.248, p = 0.154). Conclusions: We found a role for vitamin D in sleep quality of SLE patients. Further studies are warranted to confirm these results and to find possible mechanisms of action.