Observed Patterns of Systemic Disease on PET/CT Scan in Patients with Presumed Ocular Tuberculosis: Findings and Hypotheses. (17th February 2018)

• Record Type: Journal Article
• Authors: Mehta, Salil
• Is Part Of: Ocular immunology and inflammation. Volume 26:Number 2(2018)
• Page Start: 217
• Page End: 219
• Publication Date: 2018-02-17
• Subjects: Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2016.1194436
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose : To report the clinical, investigational and PET/CT scan findings of patients with presumed ocular tuberculosis and suggest a hypotheses for the pathogenesis. Methods : Retrospective case review. Included were 10 males and 17 females with an age range: 23–71 years. Results : Clinical findings include granulomatous or non-granulomatous anterior uveitis, intermediate uveitis, panuveitis, vasculitis, and multifocal serpiginous-like choroidopathy. A total of 13 PET/CT scans were normal and 14 showed systemic disease. The commonest finding was metabolically active lymphadenopathy and was seen in 14 patients. Mediastinal lymphadenitis was seen in 12 patients, 3 patients had abdominal/pelvic lymphadenopathy and 3 patients had additional cervical lymphadenopathy. Two patients had only cervical lymphadenitis. One patient had lung parenchymal disease and one had bone/joint disease. The commonest pathology was lymphadenitis. Conclusions : Uveitis is part of an immune response to mycobacteria that manifests as lymphadenitis in the chest/abdomen and as a uveitis.