Identification of sequence polymorphisms in the D-Loop region of mitochondrial DNA as a risk factor for gastric cancer. (3rd March 2016)

• Record Type: Journal Article
• Authors: Wang, Huiying; Wang, Yingnan; Zhao, Qun; Guo, Zhanjun; Zhang, Fengbin; Zhao, Yue; Zhang, Ruixing
• Is Part Of: Mitochondrial DNA. Volume 27:Number 2(2016)
• Page Start: 1045
• Page End: 1047
• Publication Date: 2016-03-03
• Subjects: D-Loop -- gastric cancer -- mtDNA -- SNPs
• DOI: 10.3109/19401736.2014.926546
• Languages: English
• ISSNs: 2380-2359

Abstract

Abstract: The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-Loop) of mitochondrial DNA (mtDNA) has been identified for their association with cancer risk in different types of cancers. We investigated the gastric cancer risk profile of D-Loop SNPs in a case-control study. The frequent alleles of nucleotides 73G/A, 235A/G, 309C/C insert, 324C/G, 16, 362T/C and 16, 519C/T were significantly associated with an increased risk for gastric cancer, whereas the frequent alleles of nucleotides 523–524AC/del were associated with resistance to gastric cancer. In conclusion, SNPs in the mtDNA D-Loop were found to be valuable markers for gastric cancer risk evaluation.