Single-cell analysis of CTCs with diagnostic precision: opportunities and challenges for personalized medicine. (2nd January 2016)

• Record Type: Journal Article
• Authors: Alberter, Barbara; Klein, Christoph A; Polzer, Bernhard
• Is Part Of: Expert review of molecular diagnostics. Volume 16:Number 1(2016)
• Page Start: 25
• Page End: 38
• Publication Date: 2016-01-02
• Subjects: circulating tumor cells -- liquid biopsy -- whole genome amplification -- molecular single-cell analysis -- CTC cultivation; Molecular diagnosis -- Periodicals; 616.0758205
• DOI: 10.1586/14737159.2016.1121099
• Languages: English
• ISSNs: 1473-7159

Abstract

Abstract : The generation of variant cancer cells is the major cause of acquired resistance against systemic therapies and consequently, of our inability to cure advanced cancer patients. Circulating tumor cells are gaining increasing clinical attention because they may enable the monitoring cancer progression and adjustment of treatment. In recent years multiple technologies for enrichment, isolation as well as molecular and functional analysis of circulating tumor cells have been developed. Implementation of these technologies in standardized and automated workflows in clinical diagnostics could provide valuable information for real-time monitoring of cancer and eventually new therapeutic strategies for the benefit of patients.