An acryl resin-based swellable microneedles for controlled release intradermal delivery of granisetron. (4th May 2018)

• Record Type: Journal Article
• Authors: Yang, Guozhong; He, Meilin; Zhang, Suohui; Wu, Man; Gao, Yunhua
• Is Part Of: Drug development and industrial pharmacy. Volume 44:Number 5(2018)
• Page Start: 808
• Page End: 816
• Publication Date: 2018-05-04
• Subjects: Swellable microneedles -- granisetron -- controlled-release -- poorly water-soluble drugs -- acrylic resin; Pharmaceutical chemistry -- Periodicals; Pharmaceutical industry -- Periodicals; Drug Industry -- Periodicals; Technology, Pharmaceutical -- Periodicals; 615.05
• DOI: 10.1080/03639045.2017.1414230
• Languages: English
• ISSNs: 0363-9045

Abstract

Abstract: Swellable microneedles (SMNs) are made of hydrogels and can deliver drug with controlled delivery rate by the cross-link density of the hydrogel. In this study, an acryl resin-based SMNs was developed for poorly water-soluble drugs. The making process of the SMNs is very simple and only need 60 min. The SMNs has high mechanical strength and is not easily broken. In-vitro release of SMNs-loaded model drug, granisetron base (GRB), was investigated. The results showed that seven days controlled release of GRB was obtained when SMNs contained pore-foaming agents (1.5% dicalcium phosphate (CaHPO4 ) and 1.5% polyvinylpyrrolidone (PVP)). The maximum amount delivered into skin was 86.158 ± 7.82% of the initial GRB (2.1 mg) loaded on SMNs preparation. Pharmacokinetics study in rats indicated a dose-dependent profile of plasma GRB concentrations and that the controlled release of 2.1 mg dose was observed for 144 hours. In conclusion, these SMNs provided a potential minimally invasive route for controlled-release systemic delivery of poorly water-soluble drugs.