Synthesis of 3-(quinolin-2-yl)indolizines through iodine-mediated sp3C–H functionalization of azaarenes. Issue 6 (19th March 2018) - Yavari, Issa
ABSTRACT: An efficient approach toward C–H bond activation using iodine-mediated sp 3 C–H bond functionalization for the synthesis of dialkyl 3-(quinolin-2-yl)indolizine-1, 2-dicarboxylates and dialkyl 3-(quinolin-2-yl)pyrrolo[2, 1- a ]isoquinoline-1, 2-dicarboxylates through 1, 3-dipolar cycloaddition reaction of nitrogen ylides with acetylenic esters is described. GRAPHICAL ABSTRACT: