Effect of normal sperm morphology rate (NSMR) on clinical outcomes and fertilization methods selection in the ultra-short-term GnRH-a protocol. (1st February 2016)

• Record Type: Journal Article
• Authors: Li, Mingzhao; Ma, Chun; Xue, Xia; Zhao, Wanqiu; Zhang, Silin; Shi, Juanzi
• Is Part Of: Gynecological endocrinology. Volume 32:Number 2(2016:Feb.)
• Page Start: 120
• Page End: 123
• Publication Date: 2016-02-01
• Subjects: Pregnancy -- sperm morphology -- ultra-short term GnRH-a protocol; Endocrine gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1
• DOI: 10.3109/09513590.2015.1092514
• Languages: English
• ISSNs: 0951-3590

Abstract

Abstract: Purpose : To investigate whether intracytoplasmic sperm injection (ICSI) can improve the clinical outcomes of the male patients with teratozoospermia in the ultra-short term GnRH-a protocol. Methods : Based on different normal sperm morphology rate (NSMR), the patients were divided into three groups as follows: NSMR = 0% group, 1% ≤NSMR <4% group and NSMR ≥4% group. Each group was compared with two fertilization type of in-vitro fertilization (IVF) and ICSI separately. Main outcomes compared were normal fertilization, high-quality embryo, transferrable embryo, implantation, pregnancy and abortion rate. Results : We observed that the total clinical pregnancy rate in single cleavage-stage embryo transfer (SET) group was significantly lower compared with double cleavage-stage embryo transfer (DET) group (23.87% versus 40.08%; p < 0.001). There was no significant difference in the aspects of female age, endometrial thickness, infertility duration and the number of retrieved oocytes among three groups ( p > 0.05). The normal fertilization, high-quality embryo, transferrable embryo, implantation, pregnancy and abortion rate of IVF and ICSI showed no significant difference among three groups ( p > 0.05). Conclusion : ICSI cannot improve clinical outcomes of the patients with teratozoospermia in the ultra-short term GnRH-a protocol.