Biodegradable uniform microspheres based on solid-in-oil-in-water emulsion for drug delivery: A comparison of homogenization and fluidic device. (September 2014)

• Record Type: Journal Article
• Authors: Ryu, Tae-Kyung; Kim, Sung Eun; Kim, Joo-Hwan; Moon, Seung-Kwan; Choi, Sung-Wook
• Is Part Of: Journal of bioactive and compatible polymers. Volume 29:Number 5(2014:Sep.)
• Page Start: 445
• Page End: 457
• Publication Date: 2014-09
• Subjects: Fluidic device -- conventional homogenization -- poly(ε-caprolactone) microspheres -- gentamicin -- microsphere formation; Biomedical materials -- Periodicals; Polymers in medicine -- Periodicals; Polymers -- Periodicals; 547.7
• DOI: 10.1177/0883911514544011
• Languages: English
• ISSNs: 0883-9115

Abstract

Based on solid-in-oil-in-water emulsification, we fabricated biodegradable poly(ϵ-caprolactone) microspheres containing gentamicin using conventional homogenization and a fluidic device. The feasibility of the poly(ϵ-caprolactone) microspheres as drug carriers was evaluated in terms of encapsulation efficiency, release behavior of gentamicin, and antimicrobial activity. The poly(ϵ-caprolactone) microspheres prepared using a fluidic device (fluidic device microspheres) had a uniform diameter and a smooth surface, whereas the poly(ϵ-caprolactone) microspheres prepared using conventional homogenization (conventional homogenization microspheres) exhibited polydisperse and a porous structure. At 0.3 wt% of gentamicin concentration, the encapsulation efficiencies of the conventional homogenization and fluidic device microspheres were 39.5% and 72.0%, respectively. In addition, a significant amount of gentamicin was only released initially from the conventional homogenization microspheres, whereas the fluidic device microspheres released gentamicin in a sustained manner for 28 days. These results confirmed the superior performances of the uniform fluidic device microspheres for drug delivery system. We further proposed a model for microsphere formation to explain the difference in performance of the conventional homogenization and fluidic device microspheres.