Active principles of Tetradenia riparia. IV. Anthelmintic activity of 8(14), 15-sandaracopimaradiene-7α, 18-diol. (24th April 2018)

• Record Type: Journal Article
• Authors: Van Puyvelde, Luc; Liu, Maoxuan; Veryser, Cedrick; De Borggraeve, Wim M.; Mungarulire, Joseph; Mukazayire, Marie Jeanne; Luyten, Walter
• Is Part Of: Journal of ethnopharmacology. Volume 216(2018)
• Page Start: 229
• Page End: 232
• Publication Date: 2018-04-24
• Subjects: Anthelmintic activity -- Caenorhabditis elegans -- Rwandese traditional medicine -- Tetradenia riparia -- 8(14), 15-sandaracopimaradiene-7α, 18-diol; Ethnopharmacology -- Periodicals; Pharmacognosy -- Periodicals; Herbs -- Periodicals; Herbs -- Periodicals; Pharmacognosy -- Periodicals; Pharmacognosie -- Périodiques; Herbes -- Périodiques; 615.1
• DOI: 10.1016/j.jep.2018.01.024
• Languages: English
• ISSNs: 0378-8741

Abstract

Abstract: Ethnopharmacological relevance: Tetradenia (T.) riparia (Hochst.) Codd (Lamiaceae), formerly known as Iboza riparia (Hochst.) N.E.Br., is one of the most frequently used medicinal plants in traditional Rwandese medicine. It was used as a remedy against a wide range of diseases including malaria, angina, yaws, dental abscesses, headache, worm infections and several kinds of fevers and aches. Aim of the study: This study aims to identify the compounds active against helminths from Tetradenia riparia . Methods: A bioassay-guided isolation of anthelmintic compounds from the leaves of Tetradenia riparia was performed using a Caenorhabditis elegans ( C. elegans ) testing model. Results: The bioassay-guided isolation led to one active compound, i.e. 8(14), 15-sandaracopimaradiene-7α, 18-diol. Its IC50 value was 5.4 ± 0.9 µg/mL (17.8 ± 2.9 µM). Conclusions: We identified the bioactive compound from Tetradenia riparia responsible for its anthelmintic activity: 8(14), 15-sandaracopimaradiene-7α, 18-diol. Although the compound and several of its bioactivities have been described before, this is the first report of its anthelmintic effect.