Daily variability in serum levels of calciprotein particles and their association with mineral metabolism parameters: A cross‐sectional pilot study. Issue 3 (20th February 2018)

• Record Type: Journal Article
• Authors: Yamada, Hodaka; Kuro‐o, Makoto; Ishikawa, San‐e; Funazaki, Shunsuke; Kusaka, Ikuyo; Kakei, Masafumi; Hara, Kazuo
• Is Part Of: Nephrology. Volume 23:Issue 3(2018)
• Page Start: 226
• Page End: 230
• Publication Date: 2018-02-20
• Subjects: calciprotein particles -- chronic kidney disease -- diabetes, fibroblast growth factor 23 -- mineral and bone disorder; Nephrology -- Periodicals; Kidneys -- Diseases -- Periodicals; Nephrologists -- Periodicals; 616.61; 616.61
• DOI: 10.1111/nep.12994
• Languages: English
• ISSNs: 1320-5358

Abstract

Abstract: Aim: Calciprotein particles (CPPs), colloidal protein‐mineral nanoparticles composed of solid‐phase calcium phosphate and serum protein fetuin‐A found in blood, are emerging as a novel component of chronic kidney disease‐mineral and bone disorder (CKD‐MBD). The relationship of CPPs with factors known to underlie the CKD‐MBD pathophysiology is not well known.The aim of this study is to examine daily variations in CPPs as well as their association with mineral metabolism parameters in normal individuals and early‐stage CKD patients. Methods: Twenty subjects (10 healthy adults, 10 diabetic patients) were enrolled. Serum CPP Fetuin‐A was measured and analyzed in relation to clinical parameters. Results: Estimated glomerular filtration rates (eGFR) were 103 ± 11 and 75 ± 24 mL/min per 1.73 m 2 in healthy adults and diabetic patients, respectively. Serum CPP Fetuin‐A (g/L) were elevated at postprandial 2 h in diabetic patients. Furthermore, serum CPP Fetuin‐A were inversely correlated with eGFR and serum 1, 25‐dihydroxyvitamin D3 and magnesium levels and were positively correlated with serum fibroblast growth factor‐23. Conclusions: These findings indicated that serum CPP Fetuin‐A were affected by food intake and may contribute to the pathophysiology of mineral metabolism in subjects with normal and moderately impaired renal function. Summary at a Glance: Fetuin CPP are important and are intimately involved in mineral trafficking and may be mediators of vascular calcification. Their origin is not defined. This paper suggests that circulating Fet‐A CPP may be related to eating in diabetics, so this is important.