Frequency‐Domain Response Analysis for Quantitative Systems Pharmacology Models. (29th November 2017)

• Record Type: Journal Article
• Authors: Schulthess, Pascal; Post, Teun M.; Yates, James; van der Graaf, Piet H.
• Is Part Of: CPT: pharmacometrics & systems pharmacology. Volume 7:Number 2(2018)
• Page Start: 111
• Page End: 123
• Publication Date: 2017-11-29
• Subjects: Pharmacokinetics -- Periodicals; Pharmacology -- Periodicals; Pharmacokinetics; Periodicals; 615.05
• DOI: 10.1002/psp4.12266
• Languages: English
• ISSNs: 2163-8306

Abstract

Abstract : Drug dosing regimen can significantly impact drug effect and, thus, the success of treatments. Nevertheless, trial and error is still the most commonly used method by conventional pharmacometric approaches to optimize dosing regimen. In this tutorial, we utilize four distinct classes of quantitative systems pharmacology models to introduce frequency‐domain response analysis, a method widely used in electrical and control engineering that allows the analytical optimization of drug treatment regimen from the dynamics of the model.