Achieving Totally Local Anticoagulation on Blood Contacting Devices. Issue 4 (4th December 2017)

• Record Type: Journal Article
• Authors: Gbyli, Rana; Mercaldi, Anna; Sundaram, Harihara; Amoako, Kagya A.
• Is Part Of: Advanced materials interfaces. Volume 5:Issue 4(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-12-04
• Subjects: blood‐contacting surfaces -- low‐fouling coatings -- multifunctional biomaterials -- nitric oxide -- systemic anticoagulations; Materials science -- Periodicals; 620.11
• DOI: 10.1002/admi.201700954
• Languages: English
• ISSNs: 2196-7350

Abstract

Abstract: The recent years have witnessed an increased activity in biocompatibility research aimed at limiting biomaterial‐induced blood coagulation. From 2008 to 2016, a total of $36 946 764.00 USD has been awarded in grants to 213 research proposals and as large as 50.4% ($18 627 854.00) of that award monies have been distributed to 101 proposals over the fiscal years of FY14 to FY16 alone. However, the complexity in blood responses to biomaterials, variability in blood function between individuals and animal species, and differences in medical device application and test setting all continue to pose difficulties in making a breakthrough in this field. This review focuses on the remaining challenges in the context of biomaterial surface interaction with blood, biomaterial properties and their influence on coagulation, old and new surface anticoagulation methods, main test systems (complement and platelet function) for evaluating those methods, limitations of modification techniques, and the current state of systemic anticoagulation usage as adjunctive therapy for controlling blood coagulation on biomaterials. Finally, ingredients necessary for advancing the field toward achieving totally local surface anticoagulation on blood contacting devices including standardization of in vitro and in‐vivo test methods are proposed. Some highlights of recent forward‐looking work and articles on local anticoagulation are also presented. Abstract : Biomaterials have and continue to play an important role in how to support and treat patients with various diseases through their use in tissue and blood interacting medical devices and drug delivery systems. This review focuses on outstanding challenges and new directions of anticlotting biomaterials research.