Highly Fluorescent Chiral N‐S‐Doped Carbon Dots from Cysteine: Affecting Cellular Energy Metabolism. (8th February 2018)

• Record Type: Journal Article
• Authors: Li, Feng; Li, Yiye; Yang, Xiao; Han, Xuexiang; Jiao, Yang; Wei, Taotao; Yang, Dayong; Xu, Huaping; Nie, Guangjun
• Is Part Of: Angewandte Chemie. Volume 130:Number 9(2018)
• Page Start: 2401
• Page End: 2406
• Publication Date: 2018-02-08
• Subjects: Chiralität -- Energiehaushalt der Zelle -- Glykolyse -- Grüne Synthesen -- Kohlenstoffpunkte; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201712453
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Cysteine‐based chiral optically active carbon dots (CDs) and their effects on cellular energy metabolism, which is vital for essential cellular functions, have been barely reported. A green and effective synthesis strategy for chiral N‐S‐doped CDs (fluorescence quantum yield ca. 41.26 %) based on hydrothermal treatment ofl ‐ ord ‐cysteine at as low as 60 °C has been developed. This suggested that cysteine was instable in aqueous solutions and acts as a warning for high‐temperature synthesis of nanomaterials using cysteine as stabilizer. Human bladder cancer T24 cells treated withl ‐CDs showed up‐regulated glycolysis, whiled ‐CDs had no similar effects. In contrast, no disturbance to the basal mitochondrial aerobic respiration of T24 cells was caused by either chiral CD.