Efficient Encapsulation of Fluorinated Drugs in the Confined Space of Water‐Dispersible Fluorous Supraparticles. Issue 51 (23rd November 2017)

• Record Type: Journal Article
• Authors: Pigliacelli, Claudia; Maiolo, Daniele; Nonappa, ; Haataja, Johannes S.; Amenitsch, Heinz; Michelet, Claire; Sánchez Moreno, Paola; Tirotta, Ilaria; Metrangolo, Pierangelo; Baldelli Bombelli, Francesca
• Is Part Of: Angewandte Chemie international edition. Volume 56:Issue 51(2017)
• Page Start: 16186
• Page End: 16190
• Publication Date: 2017-11-23
• Subjects: fluorous surfaces -- gold nanoparticles -- hydrophobin -- self-assembly -- supraparticles; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201710230
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Fluorophobic‐driven assemblies of gold nanomaterials were stabilized into water‐dispersible fluorous supraparticles by the film‐forming protein hydrophobin II. The strategy makes use of fluorous nanomaterials of different dimensions to engineer size and inner functionalization of the resulting confined space. The inner fluorous compartments allow efficient encapsulation and transport of high loadings of partially fluorinated drug molecules in water. Abstract : Fluorous supraparticles : The film‐forming protein hydrophobin II stabilizes fluorophobic‐driven assemblies of gold nanomaterials in water. Using nanomaterials of different dimensions, the size and inner functionalization of the resulting confined space can be engineered. Partially fluorinated drug molecules are encapsulated efficiently and can be transported in water.