Ancestry and dental development: A geographic and genetic perspective. Issue 2 (15th November 2017)

• Record Type: Journal Article
• Authors: Dhamo, Brunilda; Kragt, Lea; Grgic, Olja; Vucic, Strahinja; Medina‐Gomez, Carolina; Rivadeneira, Fernando; Jaddoe, Vincent W.V.; Wolvius, Eppo B.; Ongkosuwito, Edwin M.
• Is Part Of: American journal of physical anthropology. Volume 165:Issue 2(2018)
• Page Start: 299
• Page End: 308
• Publication Date: 2017-11-15
• Subjects: dental age -- genes -- geography -- maturation -- origin -- tooth; Physical anthropology -- Periodicals; Anthropology -- Periodicals; Anthropologie physique -- Périodiques; 599.9
• DOI: 10.1002/ajpa.23351
• Languages: English
• ISSNs: 0002-9483

Abstract

Abstract: Objective: In this study, we investigated the influence of ancestry on dental development in the Generation R Study. Methods: Information on geographic ancestry was available in 3, 600 children (1, 810 boys and 1, 790 girls, mean age 9.81 ± 0.35 years) and information about genetic ancestry was available in 2, 786 children (1, 387 boys and 1, 399 girls, mean age 9.82 ± 0.34 years). Dental development was assessed in all children using the Demirjian method. The associations of geographic ancestry (Cape Verdean, Moroccan, Turkish, Dutch Antillean, Surinamese Creole and Surinamese Hindustani vs Dutch as the reference group) and genetic content of ancestry (European, African or Asian) with dental development was analyzed using linear regression models. Results: In a geographic perspective of ancestry, Moroccan (β = 0.18; 95% CI: 0.07, 0.28), Turkish (β = 0.22; 95% CI: 0.12, 0.32), Dutch Antillean (β = 0.27; 95% CI: 0.12, 0.41), and Surinamese Creole (β = 0.16; 95% CI: 0.03, 0.30) preceded Dutch children in dental development. Moreover, in a genetic perspective of ancestry, a higher proportion of European ancestry was associated with decelerated dental development (β = −0.32; 95% CI: –.44, –.20). In contrast, a higher proportion of African ancestry (β = 0.29; 95% CI: 0.16, 0.43) and a higher proportion of Asian ancestry (β = 0.28; 95% CI: 0.09, 0.48) were associated with accelerated dental development. When investigating only European children, these effect estimates increased to twice as large in absolute value. Conclusion: Based on a geographic and genetic perspective, differences in dental development exist in a population of heterogeneous ancestry and should be considered when describing the physiological growth in children.