The effect of OK-432 (Picibanil) injection on the histopathology of nasal turbinate. Issue 12 (12th October 2015)

• Record Type: Journal Article
• Authors: Sengul, S; Kaygusuz, İ; Akin, M M; Yalcin, Ş; Karlidag, T; Keles, E; Arslan, İ
• Is Part Of: Journal of laryngology & otology. Volume 129:Issue 12(2015)
• Page Start: 1208
• Page End: 1212
• Publication Date: 2015-10-12
• Subjects: Turbinates, -- Hypertrophy, -- Nasal Obstruction, -- Picibanil; Otolaryngology -- Periodicals; 617.51
• DOI: 10.1017/S002221511500273X
• Languages: English
• ISSNs: 0022-2151

Abstract

Abstract: Objective: This study aimed to assess the histopathological effect of OK-432 (Picibanil) on rabbit nasal turbinates. Methods: A total of 21 rabbits were divided into 3 treatment groups and various parts of both nasal turbinates were injected with 0.5 ml OK-432, 0.2 ml OK-432 or 0.6 ml saline (control). Bilateral nasal turbinates were later excised and studied under light microscopy to assess any histopathological changes. Results: Animals in the 0.2 ml and 0.5 ml OK-432 groups exhibited mild ciliary loss, goblet cell loss and epithelial damage, and a marked increase in inflammatory cell infiltration, submucosal vascularisation and fibrosis. There was a significant difference in histopathological changes between the two OK-432 treated groups. In addition, each OK-432 treated group had significantly more inflammatory cell infiltration, increased submucosal vascularisation and fibrosis compared with controls. Conclusion: The marked fibrosis observed in OK-432-injected turbinates may be responsible for a reduction in turbinate size.