Evidence on the efficacy of primary radiosurgery or stereotactic radiotherapy for drug-resistant non-neoplastic focal epilepsy in adults: A systematic review. (February 2018)

• Record Type: Journal Article
• Authors: Eekers, Daniëlle B.P.; Pijnappel, Esther N.; Schijns, Olaf E.M.G.; Colon, Albert; Hoeben, Ann; Zindler, Jaap D.; Postma, Alida A.; Hoffmann, Aswin L.; Lambin, Philippe; Troost, Esther G.C.
• Is Part Of: Seizure. Volume 55(2018)
• Page Start: 83
• Page End: 92
• Publication Date: 2018-02
• Subjects: Stereotactic radiotherapy -- Radiosurgery -- Epileptogenic lesions -- Focal epilepsy; Epilepsy -- Periodicals; Epilepsy -- Periodicals; Seizures -- Periodicals; Épilepsie -- Périodiques; Electronic journals; Electronic journals; 616.853
• DOI: 10.1016/j.seizure.2018.01.009
• Languages: English
• ISSNs: 1059-1311

Abstract

Highlights: Systematic review on effectiveness radiotherapy in adults with drug resistant NNFE. Evidence is based on case series, randomized trials are lacking. Future: Is fractionated radiotherapy able to reduce long-term toxicity? Abstract: Purpose: Although the majority of adult epilepsy patients respond well to the current antiepileptic drug treatment, 20–40% of them are drug-resistant. In these patients, resective epilepsy surgery is a curative treatment option, for which, however, only a limited number of patients is eligible. The purpose is to summarize the outcome of radiotherapy for drug-resistant non-neoplastic focal epilepsy and to elucidate its efficacy for seizure outcome and long-term toxicity in adults. Method: A systematic literature search was performed in Pubmed, Ovid Medline, Cochrane library, Embase and Web of Science. The methodological quality was evaluated using an adapted QUADAS checklist. Results: Sixteen out of 170 initially identified studies were included in this systematic literature study (n = 170 patients). Twelve of the 16 studies described a positive effect of radiotherapy on seizure frequency reduction, with 98 of the patients (on average 58%, range 25%–95%) reporting no or rare seizures (defined as radiotherapy-adapted Engel class [RAEC] I and II. In total, 20% (34 patients) of the patients needed subsequent surgery due to radionecrosis, cysts formation, edema, and intracranial hypertension or remaining seizures. A dose-effect model was fitted to the available response data in an attempt to derive a relationship between prescribed dose and RAEC frequency. Conclusions: Radiotherapy is a possible non-invasive treatment option for patients with drug-resistant focal non-neoplastic epilepsy. This systematic review showed that there is only level 4 evidence of primary radiotherapy reducing seizure frequency in adult patients. Prospective randomized trials are needed to determine its exact value compared to other treatment approaches.