Electrophysiological response during auditory gap detection: Biomarker for sensory and communication alterations in autism spectrum disorder?. Issue 2 (17th February 2018)

• Record Type: Journal Article
• Authors: Foss-Feig, Jennifer H.; Stavropoulos, Katherine K. M.; McPartland, James C.; Wallace, Mark T.; Stone, Wendy L.; Key, Alexandra P.
• Is Part Of: Developmental neuropsychology. Volume 43:Issue 2(2018)
• Page Start: 109
• Page End: 122
• Publication Date: 2018-02-17
• Subjects: Neuropsychology -- Periodicals; 612.8
• DOI: 10.1080/87565641.2017.1365869
• Languages: English
• ISSNs: 8756-5641

Abstract

ABSTRACT: Sensory symptoms, including auditory processing deficits, are common in autism spectrum disorder (ASD). Processing of temporal aspects of auditory input is understudied; yet, deficits in this domain could contribute to language-related impairments. In children with ASD and well-matched controls, this study examined electrophysiological response to silent gaps in auditory stimuli. Results revealed attenuated amplitude of the P2 event-related potential (ERP) component in ASD. The P2 amplitude reduction was also associated with sensory, language, and diagnostic features. These results suggest that neural response during auditory gap detection is a promising ASD biomarker that could be useful for stratifying subgroups and evaluating treatment response.