A physically crosslinked polydopamine/nanocellulose hydrogel as potential versatile vehicles for drug delivery and wound healing. (15th May 2018)

• Record Type: Journal Article
• Authors: Liu, Yingying; Sui, Yulong; Liu, Chao; Liu, Changqing; Wu, Meiyan; Li, Bin; Li, Youming
• Is Part Of: Carbohydrate polymers. Volume 188(2018)
• Page Start: 27
• Page End: 36
• Publication Date: 2018-05-15
• Subjects: CNFs cellulose nanofibrils -- TEMPO 2, 2, 6, 6 tetramethylpiperidine-1-oxyl -- TOCNFs TEMPO oxidized cellulose -- PDA polydopamine -- TH tetracycline hydrochloride -- NIR near-infrared responsive -- PDI polydispersity index -- BSKP bleached softwood kraft pulp -- PDA-TH TH-loaded PDA -- DLR drug loading ratio -- PBS phosphate-buffered solution -- H & E hematoxylin and eosin -- LB lysogeny broth -- PNIPAM poly (N-isopropylacrylamide) -- GT granulation tissue -- HT host tissue; Nanocellulose -- Cellulose nanofibrils -- Polydopamine -- Hydrogel -- Drug delivery -- Wound healing; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2018.01.093
• Languages: English
• ISSNs: 0144-8617

Abstract

Graphical abstract: Highlights: A novel hydrogel was prepared via physical cross-linking of polydopamine and TOCNFs. The hydrogel showed remarkable pH, NIR response, and long period drug release. The hydrogel presented excellent wound healing and antibacterial abilities. Abstract: In this study, we reported a pH/near-infrared (NIR)-responsive hydrogel for on-demand drug delivery and wound healing. Cellulose nanofibrils (TOCNFs) were produced by 2, 2, 6, 6-tetramethylpiperidine-1-oxyl (TEMPO)-mediated oxidation method. Polydopamine (PDA) was introduced into TOCNFs network to fabricate a PDA/TOCNFs hydrogel through ion-crosslinking with calcium ion as a crosslinker. Then, tetracycline hydrochloride (TH) which loaded on PDA could be released from the prepared hydrogels in an on-demand fashion under NIR exposure or at lower pH conditions. In addition, the in vivo skin defect experiments illustrated that the resultant composite hydrogel had a synergistic effect on promoting wound healing. Therefore, owing to the unique pH/NIR responsiveness, long time period drug releasing property, antibacterial and mechanical properties, together with their biodegradability and biocompatibility, the prepared PDA/TOCNFs hydrogel is highly promising as a new drug delivery vehicle, offering simple and safe alternatives to the conventional systems based on the petroleum-based polymers.