Risk of acute coronary syndrome and peripheral arterial disease in chronic liver disease and cirrhosis: A nationwide population-based study. (March 2018)

• Record Type: Journal Article
• Authors: Lin, Shih-Yi; Lin, Cheng-Li; Lin, Cheng-Chieh; Wang, I-Kuan; Hsu, Wu-Huei; Kao, Chia-Hung
• Is Part Of: Atherosclerosis. Volume 270(2018)
• Page Start: 154
• Page End: 159
• Publication Date: 2018-03
• Subjects: Acute coronary syndrome -- Liver cirrhosis -- Peripheral arterial disease -- Cohort study; ACS acute coronary syndrome -- PAD peripheral arterial disease -- aSHR adjusted subhazard ratio -- HBV hepatitis B virus -- HCV hepatitis C virus (HCV) -- NHIRD National Health Insurance Research Database -- ICD-9-CM International Classification of Diseases -- Ninth Revision Clinical Modification -- CLDC chronic liver disease and cirrhosis; Arteriosclerosis -- Periodicals; Electronic journals; 616.136
• DOI: 10.1016/j.atherosclerosis.2018.01.047
• Languages: English
• ISSNs: 0021-9150

Abstract

Abstract: Background & aims: Until now, no study has investigated the risks of acute coronary syndrome (ACS) and peripheral arterial disease (PAD) in cirrhosis. Methods: In this study, 57, 214 patients diagnosed with cirrhosis between 2000 and 2010 were identified from the Taiwan National Health Insurance claims data. Each patient was randomly selected and frequency-matched with an individual without cirrhosis by age, sex, and index year. Results: The overall incidence rates of ACS and PAD were 2.81 and 2.97 per 1000 person-years, respectively, in the cirrhosis cohort. The cirrhosis cohort had a higher risk of ACS [adjusted subhazard ratio (aSHR) = 1.12, 95% confidence interval (CI) = 1.03–1.22] and PAD (aSHR = 1.11, 95% CI = 1.02–1.21). The risk of ACS was highest among members of the cirrhosis cohort with ascites (aSHR = 1.09, 95% CI = 1.11–1.19). Conclusions: Patients with chronic liver disease and cirrhosis have higher risks of ACS and PAD than those without chronic liver disease and cirrhosis. Highlights: The overall incidence rates of acute coronary syndrome (ACS) and peripheral arterial disease (PAD) were 2.81 and 2.97 per 1000 person-years, respectively, in the cirrhosis cohort. The cirrhosis cohort had a significantly higher risks of ACS (adjusted subhazard ratio (aSHR) = 1.12) and PAD (aSHR = 1.11).