Cu(I)-catalyzed one-pot reactions of isatins, indoles, and amines toward unsymmetrically substituted 2-carbonylarylureas. Issue 13 (29th March 2018)
- Record Type:
- Journal Article
- Title:
- Cu(I)-catalyzed one-pot reactions of isatins, indoles, and amines toward unsymmetrically substituted 2-carbonylarylureas. Issue 13 (29th March 2018)
- Main Title:
- Cu(I)-catalyzed one-pot reactions of isatins, indoles, and amines toward unsymmetrically substituted 2-carbonylarylureas
- Authors:
- Peng, Xiangjun
Xu, Xianyun
Chen, Shuangyang
Tian, Zeng
Liu, Liangxian
Liu, Qian - Abstract:
- Abstract: A series of unsymmetrical arylureas was obtained by the one-pot method for reacting isatins with indoles incorporating primary amino moieties, a significant heterocyclic skeleton for diverse pharmaceutically active structures. The reaction proceeds through Cu(I)-catalyzed C2C3 bond of the ring-opening isatins and then expands the substrates in the optimum conditions. Furthermore, selected compounds4b and4k exhibit moderate to good anti-schistosomicidal activities. Graphical abstract:
- Is Part Of:
- Tetrahedron. Volume 74:Issue 13(2018)
- Journal:
- Tetrahedron
- Issue:
- Volume 74:Issue 13(2018)
- Issue Display:
- Volume 74, Issue 13 (2018)
- Year:
- 2018
- Volume:
- 74
- Issue:
- 13
- Issue Sort Value:
- 2018-0074-0013-0000
- Page Start:
- 1505
- Page End:
- 1512
- Publication Date:
- 2018-03-29
- Subjects:
- Unsymmetrical arylurea -- Isatin -- One-pot synthesis -- Antischistosomicidal activity
Chemistry, Organic -- Periodicals
547.005 - Journal URLs:
- http://www.elsevier.com/journals ↗
- DOI:
- 10.1016/j.tet.2018.02.019 ↗
- Languages:
- English
- ISSNs:
- 0040-4020
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8796.850000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 5897.xml