Efficacy and safety of sacubitril/valsartan in patients with essential hypertension uncontrolled by olmesartan: A randomized, double‐blind, 8‐week study. Issue 1 (16th January 2018)

• Record Type: Journal Article
• Authors: Cheung, Deanna G.; Aizenberg, Diego; Gorbunov, Vladimir; Hafeez, Kudsia; Chen, Chien‐Wei; Zhang, Jack
• Is Part Of: Journal of clinical hypertension. Volume 20:Issue 1(2018)
• Page Start: 150
• Page End: 158
• Publication Date: 2018-01-16
• Subjects: blood pressure -- efficacy -- hypertension -- olmesartan -- sacubitril/valsartan -- safety; Hypertension -- Periodicals; 616.132
• DOI: 10.1111/jch.13153
• Languages: English
• ISSNs: 1524-6175

Abstract

Abstract : A majority of patients with hypertension fail to achieve blood pressure (BP) control despite treatment with commonly prescribed drugs. This randomized, double‐blind phase III trial assessed the superiority of sacubitril/valsartan 200 mg (97/103 mg) to continued olmesartan 20 mg in reducing ambulatory systolic BP after 8‐week treatment in patients with mild to moderate essential hypertension uncontrolled with olmesartan 20 mg alone. A total of 376 patients were randomized to receive either sacubitril/valsartan (n = 188) or olmesartan (n = 188). Superior reductions in 24‐hour mean ambulatory systolic BP were observed in the sacubitril/valsartan group vs the olmesartan group (−4.3 mm Hg vs −1.1 mm Hg, P < .001). Reductions in 24‐hour mean ambulatory diastolic BP and pulse pressure and office systolic BP and diastolic BP were significantly greater with sacubitril/valsartan vs olmesartan ( P < .014). A greater proportion of patients achieved BP control with sacubitril/valsartan vs olmesartan. The overall incidence of adverse events was comparable between the groups. Compared with continued olmesartan, sacubitril/valsartan was more effective and generally safe in patients with hypertension uncontrolled with olmesartan 20 mg.