"Suspicious" salivary gland FNA: Risk of malignancy and interinstitutional variability. Issue 2 (20th October 2017)

• Record Type: Journal Article
• Authors: Maleki, Zahra; Miller, James Adam; Arab, Seyedeh Elham; Fadda, Guido; Bo, Ping; Wise, Olga; Rossi, Esther Diana; Jhala, Nirag; Ashish, Chandra; Ali, Syed Z.; Wang, He
• Is Part Of: Cancer cytopathology. Volume 126:Issue 2(2018)
• Page Start: 94
• Page End: 100
• Publication Date: 2017-10-20
• Subjects: cytology -- fine‐needle aspiration (FNA) -- interinstitutional variability -- risk of malignancy -- salivary gland -- suspicious; Cancer -- Cytopathology -- Periodicals; Pathology, Cellular -- Periodicals; Cytology -- Technique -- Periodicals; 611.01815
• DOI: 10.1002/cncy.21939
• Languages: English
• ISSNs: 1934-662X

Abstract

Abstract : BACKGROUND: Fine‐needle aspiration (FNA) cytology is well accepted as a safe, reliable, minimally invasive, and cost‐effective method for the diagnosis of salivary gland lesions. Salivary gland neoplasms are often difficult to diagnose because of morphologic heterogeneity and a variety of epithelial metaplastic changes. Hence, a number of salivary gland FNA specimens yield indeterminate results. For indeterminate FNA specimens, the suspicious‐for‐malignancy (SFM) category is used when a specific neoplasm falls short in quantity or quality for the criteria for malignancy. Therefore, the findings are not sufficient for a conclusive diagnosis of malignancy. METHODS: This study was designed to evaluate the risk of malignancy (ROM) for the SFM group at 5 tertiary medical centers worldwide with the aforementioned criteria. Among 12, 606 salivary gland FNA cases between 1997 and 2014, 276 (2.2%) were reported to be SFN. Specifically, 114 suspicious cases (41%) had histological follow‐up. RESULTS: Histological follow‐up of the 114 suspicious cases showed 95 malignant tumors indicating a risk of malignancy (ROM) of 83.3%. The ROM varied between 74% and 88% for the 5 participating institutions, and a Fisher's exact test with significance set to p<.05 showed no significant difference in ROM among the institutions (p = .78). CONCLUSIONS: Overall, 83.3% of SFM salivary gland FNA specimens turned out to be malignant; there was no significant interinstitutional variability in the ROMs. The SFM category for salivary gland FNA is very homogeneous, and the ROMs are quite similar worldwide. Cancer Cytopathol 2018;126:94‐100. © 2017 American Cancer Society . Abstract : The suspicious‐for‐malignancy category in salivary gland cytology is used for lesions when a specific neoplasm falls short in quantity or quality for the criteria for malignancy. In this study, 83.3% of 114 suspicious‐for‐malignancy salivary gland fine‐needle aspiration specimens are found to be malignant, and there is no significant interinstitutional variability in the risk of malignancy.