MicroRNAs in the pathophysiology of epilepsy. (22nd February 2018)

• Record Type: Journal Article
• Authors: Brennan, Gary P.; Henshall, David C.
• Is Part Of: Neuroscience letters. Volume 667(2018)
• Page Start: 47
• Page End: 52
• Publication Date: 2018-02-22
• Subjects: Epigenetics -- Hippocampal sclerosis -- Noncoding RNA -- Oligonucleotide; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2017.01.017
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: MicroRNAs are small noncoding RNAs that regulate gene expression in epilepsy. Recent examples include miRNAs linked to control of neuroinflammation and function of dendritic potassium channels. MicroRNAs may be a novel class of target for the treatment and prevention of epilepsy. Abstract: Temporal lobe epilepsy is a common and often drug-resistant seizure disorder. The underlying pathological processes which give rise to the development of spontaneous seizures include neuroinflammation, cell loss, neurogenesis and dendritic abnormalities and many of these are driven by insult-induced changes in gene expression and gene expression regulation. MicroRNAs are powerful modulators of post-transcriptional gene expression which are dysregulated during epileptogenesis. The advent of locked nucleic acid (LNA) based inhibitory methods and mimic technology has facilitated in vivo functional assessment of these molecules in epilepsy. Here we review recent advances in our understanding of the role of these short non-coding RNAs in the pathophysiology of epilepsy.