High-frequency oscillations and mesial temporal lobe epilepsy. (22nd February 2018)

• Record Type: Journal Article
• Authors: Lévesque, Maxime; Shiri, Zahra; Chen, Li-Yuan; Avoli, Massimo
• Is Part Of: Neuroscience letters. Volume 667(2018)
• Page Start: 66
• Page End: 74
• Publication Date: 2018-02-22
• Subjects: High-frequency oscillations -- Ripples -- Fast ripples -- Mesial temporal lobe epilepsy -- Ictogenesis -- Epileptogenesis; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2017.01.047
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: High-frequency oscillations reflect the activity of networks that sustain seizures and could serve as biomarkers of epilepsy. We review here the recent findings on the cellular mechanisms of ripples and fast ripples in mesial temporal lobe epilepsy. We also address the effects of anti-epileptic drugs in animal models and patients. We raise some questions and issues related to the definition of high-frequency oscillations. Abstract: The interest of epileptologists has recently shifted from the macroscopic analysis of interictal spikes and seizures to the microscopic analysis of short events in the EEG that are not visible to the naked eye but are observed once the signal has been filtered in specific frequency bands. With the use of new technologies that allow multichannel recordings at high sampling rates and the development of computer algorithms that permit the automated analysis of extensive amounts of data, it is now possible to extract high-frequency oscillations (HFOs) between 80 and 500 Hz from the EEG; HFOs have been further categorised as ripples (80–200 Hz) and fast ripples (250–500 Hz). Within the context of epileptic disorders, HFOs should reflect the pathological activity of neural networks that sustain seizure generation, and could serve as biomarkers of epileptogenesis and ictogenesis. We review here the presumptive cellular mechanisms of ripples and fast ripples in mesial temporal lobe epilepsy. We also focus on recent findings regarding the occurrence of HFOs during epileptiform activity observed in in vitro models of epileptiform synchronization, in in vivo models of mesial temporal lobe epilepsy and in epileptic patients. Finally, we address the effects of anti-epileptic drugs on HFOs and raise some questions and issues related to the definition of HFOs.