Ferrocenyl bisoxazoline as an efficient non‐phosphorus ligand for palladium‐catalyzed copper‐free Sonogashira reaction in aqueous solution. (17th November 2017)

• Record Type: Journal Article
• Authors: Yu, Shuyan; Wu, Jingxin; He, Xinwei; Shang, Yongjia
• Is Part Of: Applied organometallic chemistry. Volume 32:Number 3(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-11-17
• Subjects: copper‐free conditions -- non‐phosphorus ligand -- Sonogashira reaction; Organometallic chemistry -- Periodicals; Organometallic compounds -- Periodicals; 547.05
• DOI: 10.1002/aoc.4156
• Languages: English
• ISSNs: 0268-2605

Abstract

Abstract : Pd(OAc)2 ‐catalyzed Sonogashira coupling reactions of alkynes and a variety of aryl halides with 1, 3‐bis(5‐ferrocenylisoxazoline‐3‐yl)benzene as an efficient non‐phosphorus ligand under copper‐free conditions are presented. The main advantages over previous methodologies include low catalyst loading (0.2 mol% Pd(OAc)2 and 0.4 mol% ferrocenyl bisoxazoline ligand are sufficient for these coupling reactions), less problematic reaction medium (water–dimethylformamide) and more convenient operation (no requirement for nitrogen protection). Abstract : 1, 3‐bis‐(5‐ferrocenylisoxazoline‐3‐yl) benzene was proved to be an excellent non‐phosphorus ligand in palladium catalyzed Sonogashira coupling reaction under copper‐free conditions. The main advantages over previous methodologies include low catalyst loading, less problematic reaction media (H2 O‐DMF) and more convenient operation (no requirement for nitrogen protection).