Mixed Micellization and Interfacial Properties of Ionic Liquid‐Type Imidazolium Gemini Surfactant with Amphiphilic Drug Amitriptyline Hydrochloride and its Thermodynamics. Issue 5 (27th June 2015)

• Record Type: Journal Article
• Authors: Patel, Rajan; Khan, Abbul Bashar; Dohare, Neeraj; Maroof Ali, Mohd.; Rajor, Hament Kumar
• Is Part Of: Journal of surfactants and detergents. Volume 18:Issue 5(2015)
• Page Start: 719
• Page End: 728
• Publication Date: 2015-06-27
• Subjects: Amitriptyline hydrochloride -- Critical micelle concentration -- Interaction parameter -- Activity coefficient -- Thermodynamics; Surface active agents -- Periodicals; Detergents -- Periodicals; 668.1
• DOI: 10.1007/s11743-015-1709-3
• Languages: English
• ISSNs: 1097-3958

Abstract

Abstract: The thermodynamics of mixed micellization of amitriptyline hydrochloride (AMT) with ionic liquid‐type imidazolium gemini surfactant ([C10 ‐4‐C10 im] Br2 ), was investigated at different mole fractions and temperatures by surface tension measurements. The deviation of the critical micelle concentration (CMC) from the ideal critical micelle concentration (CMC* ), micellar mole fraction ( X 1 m ) from ideal micellar mole fraction ( X 1 ideal ), the values of interaction parameter ( β ) and activity coefficients ( f i ) (for both mixed micelles and mixed monolayer) explained the non‐ideal behavior (i.e., synergistic behavior) of binary mixtures. The excess free energy (∆ G ex ) for the AMT‐[C10 ‐4‐C10 im] Br2 binary mixtures explained the mixed micelles stability in comparison to micelles of [C10 ‐4‐C10 im] Br2 and pure AMT. Interfacial parameters, i.e., Gibbs surface excess ( Γ max ), minimum head group area at air/water interface ( A min ), free energy of micellization ( Δ G m o ), and standard Gibbs energy of adsorption (∆ G ads o ) were also evaluated for the systems. The standard entropy of adsorption (∆ S ads o ) was found higher than the standard entropy of micellization (∆ S m o ) at all mole fractions of AMT ( α 1 ).