Synthesis, spectroscopic characterization, thermal behaviour, in vitro antimicrobial and anticancer activities of novel ruthenium tricarbonyl complexes containing monodentate V‐shaped Schiff bases. (21st December 2017)

• Record Type: Journal Article
• Authors: Ramadan, Ramadan M.; Elsheemy, Walid M.; Hassan, Nahla S.; Abdel Aziz, Ayman A.
• Is Part Of: Applied organometallic chemistry. Volume 32:Number 3(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-12-21
• Subjects: anticancer drugs -- characterization -- ruthenium tricarbonyl complexes -- V‐shaped Schiff bases; Organometallic chemistry -- Periodicals; Organometallic compounds -- Periodicals; 547.05
• DOI: 10.1002/aoc.4180
• Languages: English
• ISSNs: 0268-2605

Abstract

Abstract : The interaction of Ru3 (CO)12 with a novel family of monodentate V‐shaped Schiff base ligands (L 1–4 ; L 1 : ( E )‐1‐(4‐((4‐bromobenzylidene)amino)phenyl)ethanone, L 2 : ( E )‐1‐(3‐(4‐(dimethylamino)benzylideneamino)phenyl)ethanone, L 3 : ( E )‐1‐(4‐(4‐(dimethylamino)benzylideneamino)phenyl)ethanone, L 4 : ( E )‐1‐(3‐(3, 4‐dimethoxybenzylideneamino)phenyl)ethanone) in air under atmospheric pressure afforded the novel complexes [Ru(CO)3 (L 1–4 )2 ]. The parent ligands and their complexes were characterized using elemental analyses and spectroscopic techniques. In addition, the structure of the representative ligand L 1 was determined using single‐crystal X‐ray analysis. The stereochemistry and theoretical optimization of the three‐dimensional geometry of the ligands and their complexes were justified. In vitro antimicrobial screening against bacterial stains Escherichia coli and Staphylococcus aureus and fungus Candida albicans was conducted. Cytotoxicity of the compounds as anti‐tumour agents was evaluated against liver carcinoma (HepG2), breast carcinoma (MCF7) and colon carcinoma (HCT‐116) cell lines relative to cisplatin and doxorubicin. The complexes showed variable in vitro cytotoxic activities against the three studied cell lines, with IC50 values less than those of cis‐platin, and thus appear to be building blocks for promising anti‐tumour agents. Abstract : Interaction of Ru3 (CO)12 with a novel family of V‐shaped Schiff base ligands. Cytotoxicity of the compounds as anti‐tumour agents was evaluated against HepG2, MCF7 and HCT‐116 cell lines. The complexes showed variable activities against the three cell lines, with IC50 values less than those of cisplatin, and they appear as building blocks for promising anti‐tumour agents.