Using omics to explore complications of kidney transplantation. (12th October 2017)

• Record Type: Journal Article
• Authors: Stapleton, Caragh P.; Conlon, Peter J.; Phelan, Paul J.
• Is Part Of: Transplant international. Volume 31:Number 3(2018)
• Page Start: 251
• Page End: 262
• Publication Date: 2017-10-12
• Subjects: diabetes -- kidney transplant -- omics -- skin cancer -- tolerance -- transplant outcomes; Transplantation of organs, tissues, etc -- Periodicals; 617.95405
• DOI: 10.1111/tri.13067
• Languages: English
• ISSNs: 0934-0874

Abstract

Summary: The importance of genetic and biochemical variation in renal transplant outcomes has been clear since the discovery of the HLA in the 1950s. Since that time, there have been huge advancements in both transplantation and omics. In recent years, there has seen an increased number of genome‐, proteome‐ and transcriptome‐wide studies in the field of transplantation moving away from the earlier candidate gene/protein approaches. These areas have the potential to lead to the development of personalized treatment depending on individual molecular risk profiles. Here, we discuss recent progress and the current literature surrounding omics and renal transplant complications.