Synthesis and Characterization of New pH‐Sensitive Hydrogels Based on Poly(glycidyl methacrylate‐co‐maleic anhydride). Issue 1 (13th January 2016)

• Record Type: Journal Article
• Authors: Shohraty, Farhad; Moghadam, Peyman Najafi; Fareghi, Amir Reza; Movagharnezhad, Nasim; Khalafy, Jabbar
• Is Part Of: Advances in polymer technology. Volume 37:Issue 1(2018)
• Page Start: 120
• Page End: 125
• Publication Date: 2016-01-13
• Subjects: Cefotaxime -- Drug delivery systems -- Hydrogel -- Graft copolymers -- Poly(glycidyl methacrylate‐co‐maleic anhydride); Plastics -- Periodicals; Polymers -- Periodicals; 668.9
• DOI: 10.1002/adv.21648
• Languages: English
• ISSNs: 0730-6679

Abstract

Abstract: In the present study, two new kinds of modified poly(glycidyl methacrylate‐ co ‐maleic anhydride) hydrogels have been prepared and studied as pH‐sensitive drug carriers. At first, poly(glycidyl methacrylate‐ co ‐maleic anhydride) (PGMA‐ co ‐MA) was prepared via free‐radical polymerization of glycidyl methacrylate and maleic anhydride in the presence of benzoyl peroxide as an initiator. Then the copolymer was modified with two different kinds of amino‐containing compounds, 2‐aminopyridine and 4‐aminobutyric acid. Samples were characterized by FT‐IR and TGA analysis. Besides, the water‐swelling behavior was studied to determine the approximate swelling capacity. Then as a model, Cefotaxime drug was loaded on both hydrogels, and the release studies were carried out at different pH values (3, 7, and 8, respectively). It was concluded from the results that the amino acid–modified hydrogel has a more controlled release rate than the aminopyridine‐modified hydrogel. But generally, both of these hydrogels showed acceptable response to different pH values and can be employed as pH‐sensitive drug carriers.