Loss of fundus view as an indication for secondary enucleation in retinoblastoma. Issue 4 (8th December 2017)

• Record Type: Journal Article
• Authors: Berry, Jesse L.; Kogachi, Kaitlin; Jubran, Rima; Kim, Jonathan W.
• Is Part Of: Pediatric blood & cancer. Volume 65:Issue 4(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-12-08
• Subjects: high‐risk histopathology -- loss of fundus view -- retinoblastoma -- secondary enucleation; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.26908
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract: In this retrospective study, we evaluated loss of fundus view as an indication for secondary enucleation and associated histopathologic findings. Of 64 secondarily enucleated eyes, 24 were enucleated for loss of fundus view. Average time from loss of fundus view to enucleation was 4.7 months. Of these eyes, 22 had viable tumor cells on histopathology, but none had high‐risk features. Loss of fundus view was a common indication for secondary enucleation after chemoreduction. Given the high prevalence of viable histopathologic tumor cells, enucleation for loss of fundus view should not be significantly delayed to decrease risk of high‐risk tumor progression.